Oesophageal and proximal gastric adenocarcinomas are rare after detection of Helicobacter pylori infection.

ABSTRACT:

Background

Helicobacter pylori infection is the most important risk factor for non-proximal gastric adenocarcinoma, yet some posit it is protective against oesophageal adenocarcinoma and proximal gastric cancers.

Aims

To evaluate the incidence of and risk factors for future oesophageal and proximal gastric cancers, utilizing the largest North American cohort of patients with previously identified H pylori. Also to identify whether treatment and eradication of H pylori alter future oesophageal and proximal gastric cancer risk.

Methods

Retrospective cohort study within the Veterans Administration of 36 803 patients (median age 60.4 years; 91.8% male) with confirmed H pylori between 01 January 1994 and 31 December 2018. Primary outcome was diagnosis of future oesophageal

SUBMITTER: Kumar S 

PROVIDER: S-EPMC8063492 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature