Time-dependent diffusion MRI probes cerebellar microstructural alterations in a mouse model of Down syndrome.

ABSTRACT: The cerebellum is a complex system with distinct cortical laminar organization. Alterations in cerebellar microstructure are common and associated with many factors such as genetics, cancer and ageing. Diffusion MRI (dMRI) provides a non-invasive tool to map the brain structural organization, and the recently proposed diffusion-time (t_d )-dependent dMRI further improves its capability to probe the cellular and axonal/dendritic microstructures by measuring water diffusion at multiple spatial scales. The t_d -dependent diffusion profile in the cerebellum and its utility in detecting cerebellar disorders, however, are not yet elucidated. Here, we first deciphered the spatial correspondence between dMRI contrast and cerebellar layers, based on which the cereb

SUBMITTER: Wu D 

PROVIDER: S-EPMC8063586 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature