Genetically predicted iron status and life expectancy.

ABSTRACT:

Background & aims

Systemic iron status affects multiple health outcomes, however its net effect on life expectancy is not known. We conducted a two-sample Mendelian randomization (MR) study to investigate the association of genetically proxied iron status with life expectancy.

Methods

Using genetic data from 48,972 individuals, we identified three genetic variants as instrumental variables for systemic iron status. We obtained genetic associations of these variants with parental lifespan (n = 1,012,240) and individual survival to the 90th vs. 60th percentile age (11,262 cases and 25,483 controls). We used the inverse-variance weighted method to estimate the effect of a 1-standard deviation (SD) increase in genetically predicted serum iron on each of the life expectancy outco

SUBMITTER: Daghlas I 

PROVIDER: S-EPMC8063605 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature