De Novo Versus Secondary Metastatic EGFR-Mutated Non-Small-Cell Lung Cancer.

ABSTRACT:

Background

Metastatic epidermal growth factor receptor-mutated (EGFR⁺) non-small-cell lung cancer (NSCLC) can present de novo or following previous nonmetastatic disease (secondary). Potential differences between these two patient subsets are unclear at present.

Methods

We retrospectively analyzed characteristics of tyrosine kinase inhibitor (TKI)-treated patients with de novo vs. secondary metastatic EGFR⁺ NSCLC until December 2019 (n = 401).

Results

De novo metastatic disease was 4× more frequent than secondary (n = 83/401), but no significant differences were noted regarding age (median 66 vs. 70 years), sex (65% vs. 65% females), smoking history (67% vs. 62% never/light-smokers), and histology (both >95% adenocarcinoma).

SUBMITTER: Bozorgmehr F 

PROVIDER: S-EPMC8063726 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature