A Review of Genetic Abnormalities in Unicentric and Multicentric Castleman Disease.

ABSTRACT: Castleman disease (CD) is a rare lymphoproliferative disorder known to represent at least four distinct clinicopathologic subtypes. Large advancements in our clinical and histopathologic description of these diverse diseases have been made, resulting in subtyping based on number of enlarged lymph nodes (unicentric versus multicentric), according to viral infection by human herpes virus 8 (HHV-8) and human immunodeficiency virus (HIV), and with relation to clonal plasma cells (POEMS). In recent years, significant molecular and genetic abnormalities associated with CD have been described. However, we continue to lack a foundational understanding of the biological mechanisms driving this disease process. Here, we review all cases of CD with molecular abnormalities described in the literature

SUBMITTER: Butzmann A 

PROVIDER: S-EPMC8063830 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature