Identification and comparison of circular RNAs in preeclampsia.

ABSTRACT:

Background

Preeclampsia (PE) is a pregnancy-specific syndrome, belongs to the gestational hypertension diseases category and is considered among the causes of maternal and perinatal mortality and morbidity. However, the pathogenesis of PE is still vague.

Methods

In the present study, the circular RNA (circRNA) expression patterns of normal pregnant women and PE patients were investigated using whole RNA sequencing.

Results

A total of 151 differential expressed circRNAs were identified including 121 upregulated and 30 downregulated ones. Functional and pathway enrichment analysis was conducted on the differentially expressed circRNAs using Gene Ontology and KEGG databases. The results of this analysis indicated that several crucial biological processes and pathways wer

SUBMITTER: Ping Z 

PROVIDER: S-EPMC8063878 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature