Chance and necessity in the pleiotropic consequences of adaptation for budding yeast.

ABSTRACT: Mutations that a population accumulates during evolution in one 'home' environment may cause fitness gains or losses in other environments. Such pleiotropic fitness effects determine the evolutionary fate of the population in variable environments and can lead to ecological specialization. It is unclear how the pleiotropic outcomes of evolution are shaped by the intrinsic randomness of the evolutionary process and by the deterministic variation in selection pressures across environments. Here, to address this question, we evolved 20 replicate populations of the yeast Saccharomyces cerevisiae in 11 laboratory environments and measured their fitness across multiple conditions. We found that evolution led to diverse pleiotropic fitness gains and losses, driven by multiple types of mutations.

SUBMITTER: Jerison ER 

PROVIDER: S-EPMC8063891 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature