Ontology highlight
ABSTRACT:
SUBMITTER: Kouadri A
PROVIDER: S-EPMC8064106 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Kouadri Amal A Cormenier Johanna J Gemy Kevin K Macari Laurence L Charbonnier Peggy P Richaud Pierre P Michaud-Soret Isabelle I Alfaidy Nadia N Benharouga Mohamed M
Biomedicines 20210324 4
Cystic fibrosis (CF) is caused by mutations in the gene encoding the CF Transmembrane Conductance Regulator (CFTR), an apical chloride channel. An early inflammation (EI) in the lung of CF patients occurring in the absence of any bacterial infection has been reported. This EI has been proposed to be associated with oxidative stress (OX-S), generated by deregulations of the oxidant/antioxidant status. Recently, we demonstrated that copper (Cu), an essential trace element, mediates OX-S in bronchi ...[more]