A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is a highly heterogeneous disease. Reduced expression of focal adhesion is considered as an important prerequisite for tumor cell invasion and metastasis. However, the prognostic value of focal adhesion related genes in HCC remains to be further determined. In this study, RNA expression profiles were downloaded from public databases. A five focal adhesion related gene signature model was established by the least absolute shrinkage and selection operator Cox regression analysis, which categorized patients into high- and low-risk groups. Multivariate Cox regression analysis showed that the risk score was an independent predictor for overall survival. Single-sample gene set enrichment analysis revealed that immune status was different between the two risk groups

SUBMITTER: Lin Z 

PROVIDER: S-EPMC8064231 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature