Plasma Metabolomic Profiling in 1391 Subjects with Overweight and Obesity from the SPHERE Study.

ABSTRACT: Overweight and obesity have high prevalence worldwide and assessing the metabolomic profile is a useful approach to study their related metabolic processes. In this study, we assessed the metabolomic profile of 1391 subjects affected by overweight and obesity, enrolled in the frame of the SPHERE study, using a validated LC-MS/MS targeted metabolomic approach determining a total of 188 endogenous metabolites. Multivariable censored linear regression Tobit models, correcting for age, sex, and smoking habits, showed that 83 metabolites were significantly influenced by body mass index (BMI). Among compounds with the highest association, aromatic and branched chain amino acids (in particular tyrosine, valine, isoleucine, and phenylalanine) increased with the increment of BMI, while some glycero

SUBMITTER: Frigerio G 

PROVIDER: S-EPMC8064361 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature