High sodium intake, glomerular hyperfiltration, and protein catabolism in patients with essential hypertension.

ABSTRACT:

Aims

A blood pressure (BP)-independent metabolic shift towards a catabolic state upon high sodium (Na+) diet, ultimately favouring body fluid preservation, has recently been described in pre-clinical controlled settings. We sought to investigate the real-life impact of high Na+ intake on measures of renal Na+/water handling and metabolic signatures, as surrogates for cardiovascular risk, in hypertensive patients.

Methods and results

We analysed clinical and biochemical data from 766 consecutive patients with essential hypertension, collected at the time of screening for secondary causes. The systematic screening protocol included 24 h urine (24 h-u-) collection on usual diet and avoidance of renin-angiotensin-aldosterone system-confounding medications. Urinary 24 h-Na+ excre

SUBMITTER: Rossitto G 

PROVIDER: S-EPMC8064429 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature