Scale and Scope of Gene-Alcohol Interactions in Chronic Pancreatitis: A Systematic Review.

ABSTRACT:

Background

Excessive alcohol consumption has long been known to be the primary cause of chronic pancreatitis (CP) but genetic risk factors have been increasingly identified over the past 25 years. The scale and scope of gene-alcohol interactions in CP nevertheless remain unclear.

Methods

All studies that had obtained genetic variant data concurrently on alcoholic CP (ACP) patients, non-ACP (NACP) patients and normal controls were collated. Employing normal controls as a common baseline, paired OR_ACP and OR_NACP (odds ratios associated with ACP and NACP, respectively) values were calculated and used to assess gene-alcohol interactions.

Results

Thirteen variants involving PRSS1, SPINK1, CTRC, CLDN2, CPA1, CEL

SUBMITTER: Chen JM 

PROVIDER: S-EPMC8064432 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature