Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells.

ABSTRACT:

Aims

A hallmark of advanced atherosclerosis is inadequate immunosuppression by regulatory T (Treg) cells inside atherosclerotic lesions. Dyslipidemia has been suggested to alter Treg cell migration by affecting the expression of specific membrane proteins, thereby decreasing Treg cell migration towards atherosclerotic lesions. Besides membrane proteins, cellular metabolism has been shown to be a crucial factor in Treg cell migration. We aimed to determine whether dyslipidemia contributes to altered migration of Treg cells, in part, by affecting cellular metabolism.

Methods and results

Dyslipidemia was induced by feeding Ldlr-/- mice a western-type diet for 16-20 weeks and intrinsic changes in Treg cells affecting their migration and metabolism were examined. Dyslipidemia was

SUBMITTER: Amersfoort J 

PROVIDER: S-EPMC8064436 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature