Estimated impact of tafenoquine for Plasmodium vivax control and elimination in Brazil: A modelling study.

ABSTRACT:

Background

Despite recent intensification of control measures, Plasmodium vivax poses a major challenge for malaria elimination efforts. Liver-stage hypnozoite parasites that cause relapsing infections can be cleared with primaquine; however, poor treatment adherence undermines drug effectiveness. Tafenoquine, a new single-dose treatment, offers an alternative option for preventing relapses and reducing transmission. In 2018, over 237,000 cases of malaria were reported to the Brazilian health system, of which 91.5% were due to P. vivax.

Methods and findings

We evaluated the impact of introducing tafenoquine into case management practices on population-level transmission dynamics using a mathematical model of P. vivax transmission. The model was calibrated to reflect the tran

SUBMITTER: Nekkab N 

PROVIDER: S-EPMC8064585 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature