The Role of Intravitreal Anti-VEGF Agents in Rabbit Eye Model of Open-Globe Injury.

ABSTRACT:

Purpose

To evaluate the effects of intravitreal anti-VEGF agents in a rabbit model of open-globe injury (OGI).

Methods

OGI was induced in the right eyes of 75 Belgian rabbits by making 5 mm circumferential incision placed 6 mm behind the limbus. The rabbits were divided into 4 groups: control (n = 5), OGI group (n = 40), and intravitreal Ranibizumab and Conbercept (n = 15 each). Ranibizumab or Conbercept was injected into the vitreous at 0.5 hours, 3 days, or 7 days. Vitreous fluid was collected, and levels of growth factors and cytokines were measured by enzyme-linked immunosorbent assay (ELISA). On day 28 after OGI, B scan examination and histological examination were performed to evaluate intravitreal proliferation and formation of epiretinal fibrosis

SUBMITTER: Zhao X 

PROVIDER: S-EPMC8064804 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature