The effect of zolpidem on memory consolidation over a night of sleep.

ABSTRACT:

Study objectives

Nonrapid eye movement sleep boosts hippocampus-dependent, long-term memory formation more so than wake. Studies have pointed to several electrophysiological events that likely play a role in this process, including thalamocortical sleep spindles (12-15 Hz). However, interventional studies that directly probe the causal role of spindles in consolidation are scarce. Previous studies have used zolpidem, a GABA-A agonist, to increase sleep spindles during a daytime nap and promote hippocampal-dependent episodic memory. The current study investigated the effect of zolpidem on nighttime sleep and overnight improvement of episodic memories.

Methods

We used a double-blind, placebo-controlled within-subject design to test the a priori hypothesis that zolpidem would l

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8064806 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature