Community transmission of rotavirus infection in a vaccinated population in Blantyre, Malawi: a prospective household cohort study.

ABSTRACT:

Background

Rotavirus vaccine effectiveness is reduced among children in low-income countries. Indirect (transmission-mediated) effects of rotavirus vaccine might contribute to the total population effect of vaccination. We aimed to examine risk factors for transmission of rotavirus to household contacts in Blantyre, Malawi, and estimated the effectiveness of rotavirus vaccine in preventing transmission of infection to household contacts.

Methods

In this prospective household cohort study, we recruited children born after Sept 17, 2012, and aged at least 6 weeks (vaccine-eligible children) with acute rotavirus gastroenteritis and their household contacts, in four government health facilities in Blantyre, Malawi. Clinical data, a bulk stool sample, and 1-2 mL of serum were col

SUBMITTER: Bennett A 

PROVIDER: S-EPMC8064916 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature