SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence.

ABSTRACT:

Objective

Gastric cancer patients generally have a poor outcome, particularly those with advanced-stage disease which is defined by the increased invasion of cancer locally and is associated with higher metastatic potential. This study aimed to identify genes that were functional in the most fundamental hallmark of cancer, namely invasion. We then wanted to assess their value as biomarkers of gastric cancer progression and recurrence.

Design

Data from a cohort of patients profiled on cDNA expression arrays was interrogated using K-means analysis. This genomic approach classified the data based on patterns of gene expression allowing the identification of the genes most correlated with the invasion of GC. We evaluated the functional role of a key protein from this analysis in

SUBMITTER: Busuttil RA 

PROVIDER: S-EPMC8064978 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature