Investigating the relationship between diffusion kurtosis tensor imaging (DKTI) and histology within the normal human brain.

ABSTRACT: Measurements of water diffusion with MRI have been used as a biomarker of tissue microstructure and heterogeneity. In this study, diffusion kurtosis tensor imaging (DKTI) of the brain was undertaken in 10 healthy volunteers at a clinical field strength of 3 T. Diffusion and kurtosis metrics were measured in regions-of-interest on the resulting maps and compared with quantitative analysis of normal post-mortem tissue histology from separate age-matched donors. White matter regions showed low diffusion (0.60 ± 0.04 × 10^-3 mm²/s) and high kurtosis (1.17 ± 0.06), consistent with a structured heterogeneous environment comprising parallel neuronal fibres. Grey matter showed intermediate diffusion (0.80 ± 0.02 × 10^-3 mm²/s) and kurtosis (0.82 ± 0.05) va

SUBMITTER: Maiter A 

PROVIDER: S-EPMC8065051 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature