Forecasting the dissemination of antibiotic resistance genes across bacterial genomes.

ABSTRACT: Antibiotic resistance spreads among bacteria through horizontal transfer of antibiotic resistance genes (ARGs). Here, we set out to determine predictive features of ARG transfer among bacterial clades. We use a statistical framework to identify putative horizontally transferred ARGs and the groups of bacteria that disseminate them. We identify 152 gene exchange networks containing 22,963 bacterial genomes. Analysis of ARG-surrounding sequences identify genes encoding putative mobilisation elements such as transposases and integrases that may be involved in gene transfer between genomes. Certain ARGs appear to be frequently mobilised by different mobile genetic elements. We characterise the phylogenetic reach of these mobilisation elements to predict the potential future dissemination of kn

SUBMITTER: Ellabaan MMH 

PROVIDER: S-EPMC8065159 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature