BBSome ablation in SF1 neurons causes obesity without comorbidities.

ABSTRACT:

Objectives

The hypothalamic ventromedial nucleus (VMH) plays a major role in metabolic control, but the molecular mechanisms involved remain poorly defined. We analyzed the relevance of the BBSome, a protein complex composed of 8 Bardet-Biedl syndrome (BBS) proteins including BBS1, in VMH steroidogenic factor 1 (SF1) neurons for the control of energy homeostasis and related physiological processes.

Methods

We generated mice bearing selective BBSome disruption, through Bbs1 gene deletion, in SF1 neurons (SF1^Cre/Bbs1^fl/fl). We analyzed the consequence on body weight, glucose homeostasis, and cardiovascular autonomic function of BBSome loss in SF1 neurons.

Results

SF1^Cre/Bbs1^fl/fl mice had increased body weight and adiposity un

SUBMITTER: Rouabhi M 

PROVIDER: S-EPMC8065214 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature