Project description:This experiment aims to profile polyclonal antibody binding profiles in serum from vaccinated animals relative to antibody function in a virus neutralization assay. Rabbits received three vaccinations with a DNA vaccine encoding the spike protein of the SARS-CoV-2 index strain. Serum samples were selected based on a three-tier (low, intermediate, and high) capacity to cross-neutralize SARS-CoV-2 strains with known neutralization resistance. Following normalization of total anti-spike IgG levels, serum of each animal (n=3) were evaluated for antibody binding to 10mer cyclic constrained peptides spanning the entire spike protein and regions with known SARS-CoV-2 variant of concern spike mutations.

2023-08-31 | E-MTAB-13040 | biostudies-arrayexpress

T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.

Project description: Not available

| S-EPMC11527131 | biostudies-literature

T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.

Project description: Not available

| S-EPMC12312045 | biostudies-literature

Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements.

Project description: Not available

| S-EPMC7736786 | biostudies-literature

Hexamerization of Anti-SARS CoV IgG1 Antibodies Improves Neutralization Capacity.

Project description: Not available