Unknown

Dataset Information

0

The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys.

ABSTRACT: Neurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19. In rhesus monkey, SARS-CoV-2 invades the CNS primarily via the olfactory bulb. Thereafter, viruses rapidly spread to functional areas of the central nervous system, such as hippocampus, thalamus, and medulla oblongata. The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons, microglia, and astrocytes in the CNS. Consistently, SARS-CoV-2 infects neuro-derived SK-N-SH, glial-derived U251, and brain microvascular endothelial cells in vitro. To our knowledge, this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model, which provides important insights into the CNS-related pathogenesis of SARS-CoV-2.

SUBMITTER: Jiao L 

PROVIDER: S-EPMC8065334 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Neurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19. In rhesus monkey, SARS-CoV-2 invades the CNS primarily via the olfactory bulb. Thereafter, viruses rapidly spread to functional areas of the central nervous system, such as hippocampus, thalamus, and medulla oblongata. The infection of SARS-  ...[more]

Similar Datasets

Transcriptomics SARS-CoV-2 Invades the Central Nervous System via the Olfactory Route in Rhesus Monkeys
2021-04-14 | GSE167319 | GEO
Genomics SARS-CoV-2 Invades the Central Nervous System via the Olfactory Route in Rhesus Monkeys
| PRJNA704283 | ENA
Unknown Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys.
| S-EPMC5426912 | biostudies-literature
Unknown Rapid Nipah virus entry into the central nervous system of hamsters via the olfactory route.
| S-EPMC3471094 | biostudies-literature
Unknown Leukaemia hijacks a neural mechanism to invade the central nervous system.
| S-EPMC10257142 | biostudies-literature
Transcriptomics Leukemia hijacks a neural mechanism to invade the central nervous system
2018-07-12 | GSE114627 | GEO
Unknown Olfactory bulb SARS-CoV-2 infection is not paralleled by the presence of virus in other central nervous system areas.
| S-EPMC8447476 | biostudies-literature
Unknown Enterovirus-A71 exploits peripherin and Rac1 to invade the central nervous system.
| S-EPMC8183415 | biostudies-literature
Unknown Enterovirus-A71 exploits peripherin and Rac1 to invade the central nervous system
| S-SCDT-EMBOR-2020-51777-T | biostudies-other
Unknown <i>Chlamydia muridarum</i> Can Invade the Central Nervous System <i>via</i> the Olfactory and Trigeminal Nerves and Infect Peripheral Nerve Glial Cells.
| S-EPMC7819965 | biostudies-literature