"Let Food Be Thy Medicine": Gluten and Potential Role in Neurodegeneration.

ABSTRACT: Wheat is a most favored staple food worldwide and its major protein is gluten. It is involved in several gluten dependent diseases and lately was suggested to play a role in non-celiac autoimmune diseases. Its involvement in neurodegenerative conditions was recently suggested but no cause-and-effect relationship were established. The present narrative review expands on various aspects of the gluten-gut-brain axes events, mechanisms and pathways that connect wheat and gluten consumption to neurodegenerative disease. Gluten induced dysbiosis, increased intestinal permeabillity, enteric and systemic side effects, cross-reactive antibodies, and the sequence of homologies between brain antigens and gluten are highlighted. This combination may suggest molecular mimicry, alluding to some autoimmu

SUBMITTER: Lerner A 

PROVIDER: S-EPMC8065505 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature