Improvement of Platelet Respiration by Cell-Permeable Succinate in Diabetic Patients Treated with Statins.

ABSTRACT: Diabetes mellitus (DM) is the most severe metabolic disease that reached the level of a global pandemic and is associated with high cardiovascular morbidity. Statins are the first-line lipid-lowering therapy in diabetic patients with or without a history of atherosclerotic disease. Although well tolerated, chronic treatment may result in side effects that lead to treatment interruption. Mitochondrial dysfunction has emerged as a central pathomechanism in DM- and statin-induced side effects. Assessment of mitochondrial respiration in peripheral platelets has been increasingly used as a mirror of organ mitochondrial dysfunction. The present study aimed to assess the: (i) changes in mitochondrial respiration elicited by statins in patients with type 2 DM and (ii) the effects of cell-permeable

SUBMITTER: Avram VF 

PROVIDER: S-EPMC8065590 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature