Transcription Factor Activity Inference in Systemic Lupus Erythematosus.

ABSTRACT:

Background

Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease with diverse clinical manifestations. Although most of the SLE-associated loci are located in regulatory regions, there is a lack of global information about transcription factor (TFs) activities, the mode of regulation of the TFs, or the cell or sample-specific regulatory circuits. The aim of this work is to decipher TFs implicated in SLE.

Methods

In order to decipher regulatory mechanisms in SLE, we have inferred TF activities from transcriptomic data for almost all human TFs, defined clusters of SLE patients based on the estimated TF activities and analyzed the differential activity patterns among SLE and healthy samples in two different cohorts. The Transcription Factor activity matrix was use

SUBMITTER: Lopez-Dominguez R 

PROVIDER: S-EPMC8065841 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature