Targeting Biofilm of MDR Providencia stuartii by Phages Using a Catheter Model.

ABSTRACT: Providencia spp. are emerging pathogens mainly in nosocomial infections. Providencia stuartii in particular is involved in urinary tract infections and contributes significantly to the high incidence of biofilm-formation in catheterized patients. Furthermore, recent reports suggested a role for multiple drug resistant (MDR) P. stuartii in hospital-associated outbreaks which leads to excessive complications resulting in challenging treatments. Phage therapy is currently one of the most promising solutions to combat antibiotic-resistant infections. However, the number of available phages targeting Providencia spp. is extremely limited, restricting the use of phage therapy in such cases. In the present study, we describe the isolation and characterization of 17 lytic and temperate bacteriopha

SUBMITTER: Rakov C 

PROVIDER: S-EPMC8065852 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature