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Cytotoxic Polyketide Metabolites from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus Pleosporales sp. NBUF144.

ABSTRACT: Two new polyketide natural products, globosuxanthone F (1), and 2'-hydroxy bisdechlorogeodin (2), were isolated from the fungus Pleosporales sp. NBUF144, which was derived from a 62 m deep Chalinidae family sponge together with four known metabolites, 3,4-dihydroglobosuxanthone A (3), 8-hydroxy-3-methylxanthone-1-carboxylate (4), crosphaeropsone C (5), and 4-megastigmen-3,9-dione (6). The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR and high-resolution electrospray ionization mass spectra (HRESIMS) data. The absolute configuration of 1 was further established by single-crystal X-ray diffraction studies. Compounds 1-5 were evaluated for cytotoxicity towards CCRF-CEM human acute lymphatic leukemia cells, and it was found that 1 had an IC50 value of 0.46 µM.

SUBMITTER: Zhou J 

PROVIDER: S-EPMC8065988 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Cytotoxic Polyketide Metabolites from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus <i>Pleosporales</i> sp. NBUF144.

Zhou Jing J   Zhang Hairong H   Ye Jing J   Wu Xingxin X   Wang Weiyi W   Lin Houwen H   Yan Xiaojun X   Lazaro J Enrico H JEH   Wang Tingting T   Naman C Benjamin CB   He Shan S  

Marine drugs 20210326 4

Two new polyketide natural products, globosuxanthone F (<b>1</b>), and 2'-hydroxy bisdechlorogeodin (<b>2</b>), were isolated from the fungus <i>Pleosporales</i> sp. NBUF144, which was derived from a 62 m deep Chalinidae family sponge together with four known metabolites, 3,4-dihydroglobosuxanthone A (<b>3</b>), 8-hydroxy-3-methylxanthone-1-carboxylate (<b>4</b>), crosphaeropsone C (<b>5</b>), and 4-megastigmen-3,9-dione (<b>6</b>). The structures of these compounds were elucidated on the basis  ...[more]

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