A Uremic Goat Model Created by Subtotal Renal Artery Embolization and Gentamicin.

ABSTRACT: A large animal model of (end-stage) kidney disease (ESKD) is needed for the preclinical testing of novel renal replacement therapies. This study aimed to create stable uremia via subtotal renal artery embolization in goats and induce a temporary further decline in kidney function by administration of gentamicin. Renal artery embolization was performed in five Dutch white goats by infusing polyvinyl alcohol particles in branches of the renal artery, aiming for the embolization of ~80% of one kidney and complete embolization of the contralateral kidney. Gentamicin was administered to temporarily further increase the plasma concentrations of uremic toxins. After initial acute kidney injury, urea and creatinine plasma concentrations stabilized 1.5 ± 0.7 months post-embolization and remained el

SUBMITTER: van Gelder MK 

PROVIDER: S-EPMC8066079 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature