The Interplay of RNA Binding Proteins, Oxidative Stress and Mitochondrial Dysfunction in ALS.
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ABSTRACT:
SUBMITTER: Harley J
PROVIDER: S-EPMC8066094 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
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The Interplay of RNA Binding Proteins, Oxidative Stress and Mitochondrial Dysfunction in ALS.
Harley Jasmine J Clarke Benjamin E BE Patani Rickie R
Antioxidants (Basel, Switzerland) 20210402 4
RNA binding proteins fulfil a wide number of roles in gene expression. Multiple mechanisms of RNA binding protein dysregulation have been implicated in the pathomechanisms of several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Oxidative stress and mitochondrial dysfunction also play important roles in these diseases. In this review, we highlight the mechanistic interplay between RNA binding protein dysregulation, oxidative stress and mitochondrial dysfunction in ALS ...[more]
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