Dynamic Expression of Imprinted Genes in the Developing and Postnatal Pituitary Gland.

ABSTRACT: In mammals, imprinted genes regulate many critical endocrine processes such as growth, the onset of puberty and maternal reproductive behaviour. Human imprinting disorders (IDs) are caused by genetic and epigenetic mechanisms that alter the expression dosage of imprinted genes. Due to improvements in diagnosis, increasing numbers of patients with IDs are now identified and monitored across their lifetimes. Seminal work has revealed that IDs have a strong endocrine component, yet the contribution of imprinted gene products in the development and function of the hypothalamo-pituitary axis are not well defined. Postnatal endocrine processes are dependent upon the production of hormones from the pituitary gland. While the actions of a few imprinted genes in pituitary development and function h

SUBMITTER: Scagliotti V 

PROVIDER: S-EPMC8066104 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature