LPA₁ Receptor Promotes Progesterone Receptor Phosphorylation through PKCα in Human Glioblastoma Cells.

ABSTRACT: Lysophosphatidic acid (LPA) induces a wide range of cellular processes and its signaling is increased in several cancers including glioblastoma (GBM), a high-grade astrocytoma, which is the most common malignant brain tumor. LPA₁ receptor is expressed in GBM cells and its signaling pathways activate protein kinases C (PKCs). A downstream target of PKC, involved in GBM progression, is the intracellular progesterone receptor (PR), which can be phosphorylated by this enzyme, increasing its transcriptional activity. Interestingly, in GBM cells, PKCα isotype translocates to the nucleus after LPA stimulation, resulting in an increase in PR phosphorylation. In this study, we determined that LPA₁ receptor activation induces protein-protein interaction between PKCα and PR in h

SUBMITTER: Valdes-Rives SA 

PROVIDER: S-EPMC8066126 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature