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Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 Following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project.

ABSTRACT: Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project gathered ST1 IPD surveillance data from sites globally and aimed to estimate PCV10/13 impact on ST1 IPD incidence. We estimated ST1 IPD incidence rate ratios (IRRs) comparing the pre-PCV10/13 period to each post-PCV10/13 year by site using a Bayesian multi-level, mixed-effects Poisson regression and all-site IRRs using a linear mixed-effects regression (N = 45 sites). Following PCV10/13 introduction, the incidence rate (IR) of ST1 IPD declined among all ages. After six years of PCV10/13 use, the all-site IRR was 0.05 (95% credibility interval 0.04-0.06) for all ages, 0.05 (0.04-0.05) for <5 years of age, 0.08 (0.06-0.09) for 5-17 years, 0.06 (0.05-0.08) for 18-49 years, 0.06 (0.05-0.07) for 50-64 years, and 0.05 (0.04-0.06) for ≥65 years. PCV10/13 use in infant immunization programs was followed by a 95% reduction in ST1 IPD in all ages after approximately 6 years. Limited data availability from the highest ST1 disease burden countries using a 3+0 schedule constrains generalizability and data from these settings are needed.

SUBMITTER: Bennett JC

PROVIDER: S-EPMC8066231 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Changes in Invasive Pneumococcal Disease Caused by <i>Streptococcus pneumoniae</i> Serotype 1 Following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project.

Bennett Julia C JC Hetrich Marissa K MK Garcia Quesada Maria M Sinkevitch Jenna N JN Deloria Knoll Maria M Feikin Daniel R DR Zeger Scott L SL Kagucia Eunice W EW Cohen Adam L AL Ampofo Krow K Brandileone Maria-Cristina C MC Bruden Dana D Camilli Romina R Castilla Jesús J Chan Guanhao G Cook Heather H Cornick Jennifer E JE Dagan Ron R Dalby Tine T Danis Kostas K de Miguel Sara S De Wals Philippe P Desmet Stefanie S Georgakopoulou Theano T Gilkison Charlotte C Grgic-Vitek Marta M Hammitt Laura L LL Hilty Markus M Ho Pak-Leung PL Jayasinghe Sanjay S Kellner James D JD Kleynhans Jackie J Knol Mirjam J MJ Kozakova Jana J Kristinsson Karl G KG Ladhani Shamez N SN MacDonald Laura L Mackenzie Grant A GA Mad'arová Lucia L McGeer Allison A Mereckiene Jolita J Morfeldt Eva E Mungun Tuya T Muñoz-Almagro Carmen C Nuorti J Pekka JP Paragi Metka M Pilishvili Tamara T Puentes Rodrigo R Saha Samir K SK Sahu Khan Aalisha A Savrasova Larisa L Scott J Anthony JA Skoczyńska Anna A Suga Shigeru S van der Linden Mark M Verani Jennifer R JR von Gottberg Anne A Winje Brita A BA Yildirim Inci I Zerouali Khalid K Hayford Kyla K

Microorganisms 20210327 4

<i>Streptococcus pneumoniae</i> serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project gathered ST1 IPD surveillance data from sites globally and aimed to estimate PCV10/13 impact on ST1 IPD incidence. We estimated ST1 IPD incidence rate ratios (IRRs) comparing the pre-PCV10/13 period to ea ...[more]

PMID: 33801760

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Project description:BackgroundTo mitigate the burden of pneumococcal infections in Niger, a 13-valent pneumococcal vaccine, PCV13, was introduced for routine child vaccination in July 2014. In order to provide pre-vaccine baseline data and allow appreciation of changes on carriage due to vaccination, we analyzed retrospectively pneumococcal isolates obtained from healthy, 0 to 2 year old children prior to the vaccine introduction.MethodsFrom June 5, 2007, to May 26, 2008, 1200 nasopharyngeal swabs were collected from healthy 0 to 2 year old children and analyzed by standard microbiological methods. Serotyping was done by SM-PCR and the data were analyzed with R version 2.15.0 (2012-03-30).ResultsStreptococcus pneumoniae was detected in 654/1200 children (54.5%) among whom 339 (51.8%) were males. The ages of the study subjects varied from few days to 26 months (mean = 7.1, median = 6, 95% CI [6.8-7.4]). Out of 654 frozen isolates, 377 (54.8%) were able to be re-grown and analyzed. In total, 32 different serogroups/serotypes were detected of which, the most prevalent were 6/(6A/6B/6C/6D) (15.6%), 23F (10.6%), 19F (9.3%), 14 (9%), 19A (5.6%), 23B (4.0%), 25F/38 (3.7%), 18/(18A/18B/18C/18F) (2.9%) and PCR non-typeable (16.4%). Eleven serogroups/serotypes accounting for 57.3% (216/377) were of PCV13 types. Of the 211/377 (56%) isolates tested for drug sensitivity, 23/211 (10.9%), 24/211 (11.4%), 9/211(4.3%) and 148/210 (70.5%) were respectively resistance to oxacillin, chloramphenicol, erythromycin and tetracycline. Thirteen of the oxacillin resistant isolates were additionally multidrug-resistant. No resistance was however detected to gentamycin500μg and to fluoroquinolones (ø Norfloxacin5μg <7mm). Age > 3 months and presence in family of more than one sibling aged < 6 years were significant risk factors for carriage.ConclusionA global rate of 54.5% pneumococcal carriage was detected in this study. The introduced PCV13 vaccine should cover 57.3% (216/377) of circulating serogroups/serotypes, among which were those resistant to antibiotics. Age > 3 months and presence in family of children aged < 6 years were significant factors for pneumococcal carriage. The present data should help understanding post vaccine introduction changes in pneumococcal carriage and infections for better action.

Dataset Information

Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 Following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project.

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Changes in Invasive Pneumococcal Disease Caused by <i>Streptococcus pneumoniae</i> Serotype 1 Following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project.

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Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 Following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project.

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Changes in Invasive Pneumococcal Disease Caused by &lt;i&gt;Streptococcus pneumoniae&lt;/i&gt; Serotype 1 Following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project.

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OmicsDI is part of the ELIXIR infrastructure

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Changes in Invasive Pneumococcal Disease Caused by <i>Streptococcus pneumoniae</i> Serotype 1 Following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project.