Finding associations in a heterogeneous setting: statistical test for aberration enrichment.
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ABSTRACT:
SUBMITTER: Mezlini AM
PROVIDER: S-EPMC8066476 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Finding associations in a heterogeneous setting: statistical test for aberration enrichment.
Mezlini Aziz M AM Das Sudeshna S Goldenberg Anna A
Genome medicine 20210423 1
Most two-group statistical tests find broad patterns such as overall shifts in mean, median, or variance. These tests may not have enough power to detect effects in a small subset of samples, e.g., a drug that works well only on a few patients. We developed a novel statistical test targeting such effects relevant for clinical trials, biomarker discovery, feature selection, etc. We focused on finding meaningful associations in complex genetic diseases in gene expression, miRNA expression, and DNA ...[more]
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