Potent Antiviral Activity against HSV-1 and SARS-CoV-2 by Antimicrobial Peptoids.

ABSTRACT: Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2, affect millions of people each year. However, there are few antiviral drugs that can effectively treat these infections. The standard approach in the development of antiviral drugs involves the identification of a unique viral target, followed by the design of an agent that addresses that target. Antimicrobial peptides (AMPs) represent a novel source of potential antiviral drugs. AMPs have been shown to inactivate numerous different enveloped viruses through the disruption of their viral envelopes. However, the clinical development of AMPs as antimicrobial therapeutics has been hampered by a number of factors, especially their enzymatically labile structure as peptides. We have examined the antiviral p

SUBMITTER: Diamond G 

PROVIDER: S-EPMC8066833 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature