Cost effectiveness analysis of a polygenic risk tailored breast cancer screening programme in Singapore.

ABSTRACT:

Background

This study aimed to evaluate the cost-effectiveness of a breast cancer screening programme that incorporates genetic testing using breast cancer associated single nucleotide polymorphisms (SNPs), against the current biennial mammogram-only screening programme to aid in its implementation into the current programme in Singapore.

Methods

A Markov model was used to compare the costs and health outcomes of the current screening programme, against a polygenic risk-tailored screening programme, which can advise a long-term screening strategy depending on the individual's polygenic risk. The model took the perspective of the healthcare system, with a time horizon of 40 years, following women from the age of 35 to 74. Epidemiological and cost data were taken from Asian st

SUBMITTER: Wong JZY 

PROVIDER: S-EPMC8066868 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature