Brain Dynamics Altered by Photic Stimulation in Patients with Alzheimer's Disease and Mild Cognitive Impairment.

ABSTRACT: Individuals with mild cognitive impairment (MCI) are at high risk of developing Alzheimer's disease (AD). Repetitive photic stimulation (PS) is commonly used in routine electroencephalogram (EEG) examinations for rapid assessment of perceptual functioning. This study aimed to evaluate neural oscillatory responses and nonlinear brain dynamics under the effects of PS in patients with mild AD, moderate AD, severe AD, and MCI, as well as healthy elderly controls (HC). EEG power ratios during PS were estimated as an index of oscillatory responses. Multiscale sample entropy (MSE) was estimated as an index of brain dynamics before, during, and after PS. During PS, EEG harmonic responses were lower and MSE values were higher in the AD subgroups than in HC and MCI groups. PS-induced changes in EEG

SUBMITTER: Yu WY 

PROVIDER: S-EPMC8066899 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature