Optimization of Two Steps in Scale-Up Synthesis of Nannocystin A.

ABSTRACT: We have accomplished a 10-step (longest linear) total synthesis of nannocystin A on a four hundred milligram scale. The previously reported Kobayashi vinylogous Mukaiyama aldol reaction to connect C4 and C5 was unreproducible during the scaling up process. A more convenient and cost-efficient Keck asymmetric vinylogous aldol reaction was employed to improve this transformation.

SUBMITTER: Zhang T 

PROVIDER: S-EPMC8066987 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature