Phosphatidylinositol Stabilizes Fluid-Phase Liposomes Loaded with a Melphalan Lipophilic Prodrug.

ABSTRACT: Previously, a liposomal formulation of a chemotherapeutic agent melphalan (Mlph) incorporated in a fluid lipid bilayer of natural phospholipids in the form of dioleoylglyceride ester (MlphDG) was developed and the antitumor effect was confirmed in mouse models. The formulation composed of egg phosphatidylcholine (ePC), soybean phosphatidylinositol (PI), and MlphDG (8:1:1, by mol) showed stability in human serum for at least 4-5 h. On the contrary, replacing PI with pegylation of the liposomes, promoted fast dissociation of the components from the bilayer. In this work, interactions of MlphDG-liposomes with the most abundant plasma protein-albumin-in function of the presence of PI in the formulation were explored using Fourier transform infrared spectroscopy. The release of MlphDG from the

SUBMITTER: Tretiakova D 

PROVIDER: S-EPMC8067299 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature