Penile Cancer-Derived Cells Molecularly Characterized as Models to Guide Targeted Therapies.

ABSTRACT: Penile cancer (PeCa) is a common disease in poor and developing countries, showing high morbidity rates. Despite the recent progress in understanding the molecular events involved in PeCa, the lack of well-characterized in vitro models precludes new advances in anticancer drug development. Here we describe the establishment of five human primary penile cancer-derived cell cultures, including two epithelial and three cancer-associated fibroblast (CAF) cells. Using high-throughput genomic approaches, we found that the epithelial PeCa derived- cells recapitulate the molecular alterations of their primary tumors and present the same deregulated signaling pathways. The differentially expressed genes and proteins identified are components of key oncogenic pathways, including EGFR and PI3K/AKT/mT

SUBMITTER: Kuasne H 

PROVIDER: S-EPMC8067406 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature