A New Strain of Christensenella minuta as a Potential Biotherapy for Obesity and Associated Metabolic Diseases.

ABSTRACT: Obesity is associated with gut microbiota dysbiosis, characterized by a high Firmicutes/Bacteroidetes ratio. Gut-dwelling bacteria of the Christensenellaceae family have been proposed to act as keystones of the human gut ecosystem and to prevent adipogenesis. The objectives of the present study were to demonstrate the antiobesity potential of a new strain of Christensenella minuta in preclinical models and explore related mechanisms of action. The antiobesity potential of C. minuta DSM33407 was assessed in a diet-induced obesity mouse model. Changes in hepatic lipid metabolism were explored using targeted transcriptomics. Effects on gut microbiota were further assessed in a humanized Simulator of the Human Intestinal Microbial Ecosystem (SHIME^®) model inoculated wi

SUBMITTER: Mazier W 

PROVIDER: S-EPMC8067450 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature