Genetic Regulation of Biomarkers as Stress Proxies in Dairy Cows.

ABSTRACT: Stress in livestock reduces productivity and is a welfare concern. At a physiological level, stress is associated with the activation of inflammatory responses and increased levels of harmful reactive oxygen species. Biomarkers that are indicative of stress could facilitate the identification of more stress-resilient animals. We examined twenty-one metabolic, immune response, and liver function biomarkers that have been associated with stress in 416 Italian Simmental and 436 Italian Holstein cows which were genotyped for 150K SNPs. Single-SNP and haplotype-based genome-wide association studies were carried out to assess whether the variation in the levels in these biomarkers is under genetic control and to identify the genomic loci involved. Significant associations were found for the plas

SUBMITTER: Milanesi M 

PROVIDER: S-EPMC8067459 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature