NLossFinder-A Graphical User Interface Program for the Nontargeted Detection of DNA Adducts.

ABSTRACT: DNA adductomics is a relatively new omics approach aiming to measure known and unknown DNA modifications, called DNA adducts. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the most common method for analyzing DNA adducts. Recent advances in the field of mass spectrometry have allowed the possibility to perform a comprehensive analysis of adducts, for instance, by using a nontargeted data-independent acquisition method, with multiple precursor m/z windows as an inclusion list. However, the generated data are large and complex, and there is a need to develop algorithms to simplify and automate the time-consuming manual analysis that has hitherto been used. Here, a graphical user interface (GUI) program was developed, with the purpose of tracking a characteristic neutra

SUBMITTER: Sousa PFM 

PROVIDER: S-EPMC8067598 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature