Functionalized Peptide Fibrils as a Scaffold for Active Substances in Wound Healing.

ABSTRACT: Technological developments in the field of biologically active peptide applications in medicine have increased the need for new methods for peptide delivery. The disadvantage of peptides as drugs is their low biological stability. Recently, great attention has been paid to self-assembling peptides that can form fibrils. Such a formulation makes bioactive peptides more resistant to enzymatic degradation and druggable. Peptide fibrils can be carriers for peptides with interesting biological activities. These features open up prospects for using the peptide fibrils as long-acting drugs and are a valid alternative to conventional peptidic therapies. In our study, we designed new peptide scaffolds that are a hybrid of three interconnected amino acid sequences and are: pro-regenerative, cleavabl

SUBMITTER: Sawicka J 

PROVIDER: S-EPMC8067766 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature