Patient-specific in vitro testing for evaluating TAVR clinical performance-A complementary approach to current ISO standard testing.

ABSTRACT: Following in vitro tests established for surgical prosthetic heart valves, transcatheter aortic valves (TAV) are similarly tested in idealized geometries-excluding effects that may hamper TAVR performance in situ. Testing in vitro in pulse duplicator systems that incorporated patient-specific replicas would enhance the testing veracity by bringing it closer to the clinical scenario. To that end we compare TAV hemodynamic performance tested in idealized geometries according to the ISO standard (baseline performance) to that obtained by testing the TAVs following deployment in patient-specific replicas. Balloon-expandable (n = 2) and self-expandable (n = 3) TAVs were tested in an idealized geometry in mock-circulation system (following ISO 5840-3 guidelines) and compared to the measurements

SUBMITTER: Kovarovic BJ 

PROVIDER: S-EPMC8068093 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature