Low Serum Uric Acid Predicts Risk of a Composite Disease Endpoint.

ABSTRACT: Background and objectives: Mortality may increase in hypouricemia as well as inhyperuricemia. We assessed the predictive value of low serum uric acid (SUA) levels on the risk of overall mortality or a composite endpoint of death and nonfatal events. Materials and Methods: In 1013 community-based middle-aged adults, free of uncontrolled diabetes and coronary heart disease at baseline, the association of sex-specific SUA tertiles with defined outcomes was evaluated prospectively by logistic regression, stratified to gender and presence of type-2 diabetes, using recent criteria. Results: Totally, 43 deaths and additional incident nonfatal events in 157 cases were recorded at a median 3.4 years' follow-up. Multivariable linear regression disclosed SUA to be significantly associated among non-d

SUBMITTER: Ozpamuk-Karadeniz F 

PROVIDER: S-EPMC8068308 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature