Antiplatelet and Antithrombotic Effects of Epimedium koreanum Nakai.

ABSTRACT: Background and Objective. Epimedium koreanum Nakai is a medicinal plant known for its health beneficial effects on impotence, arrhythmia, oxidation, aging, osteoporosis, and cardiovascular diseases. However, there is no report available that shows its effects on platelet functions. Here, we elucidated antiplatelet and antithrombotic effects of ethyl acetate fraction of E. koreanum. Methodology. We analyzed the antiplatelet properties using standard in vitro and in vivo techniques, such as light transmission aggregometry, scanning electron microscopy, intracellular calcium mobilization measurement, dense granule secretion, and flow cytometry to assess integrin α _IIb β ₃ activation, clot retraction, and Western blo

SUBMITTER: Irfan M 

PROVIDER: S-EPMC8068545 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature