Indirect White Matter Pathways Are Associated With Treated Naming Improvement in Aphasia.

ABSTRACT:

Background

White matter disconnection of language-specific brain regions associates with worse aphasia recovery. Despite a loss of direct connections, many stroke survivors may maintain indirect connections between brain regions.

Objective

To determine (1) whether preserved direct connections between language-specific brain regions relate to better poststroke naming treatment outcomes compared to no direct connections and (2) whether for individuals with a loss of direct connections, preserved indirect connections are associated with better treatment outcomes compared to individuals with no connections.

Methods

We computed structural whole-brain connectomes from 69 individuals with chronic left-hemisphere stroke and aphasia who completed a 3-week-long language treatme

SUBMITTER: Wilmskoetter J 

PROVIDER: S-EPMC8068606 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature