Differential effects of sex on longitudinal patterns of cognitive decline in Parkinson's disease.

ABSTRACT:

Background

Cognitive impairment is an important and diverse symptom of Parkinson's disease (PD). Sex is a purported risk variable for cognitive decline in PD, but has not been comprehensively investigated.

Objectives

This cross-sectional and longitudinal study examined sex differences in global and domain-specific cognitive performance in a large PD cohort.

Methods

Cognitive function was evaluated using the Addenbrooke's Cognitive Examination in 392 people with PD (PwP) from the Australian Parkinson's Disease Registry. The influence of sex on domain-specific cognitive performance was investigated using covariate-corrected generalised linear models. In a repeated measures longitudinal subset of 127 PwP, linear mixed models were used to assess the impact of sex on cogni

SUBMITTER: Bakeberg MC 

PROVIDER: S-EPMC8068663 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature