Ontology highlight
ABSTRACT:
SUBMITTER: Dell'Anno I
PROVIDER: S-EPMC8068714 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Dell'Anno Irene I Martin Sarah A SA Barbarino Marcella M Melani Alessandra A Silvestri Roberto R Bottaro Maria M Paolicchi Elisa E Corrado Alda A Cipollini Monica M Melaiu Ombretta O Giordano Antonio A Luzzi Luca L Gemignani Federica F Landi Stefano S
Investigational new drugs 20201209 3
Objectives Malignant pleural mesothelioma (MPM) is an occupational disease mainly due to asbestos exposure. Effective therapies for MPM are lacking, making this tumour type a fatal disease. Materials and Methods In order to meet this need and in view of a future "drug repositioning" approach, here we screened five MPM (Mero-14, Mero-25, IST-Mes2, NCI-H28 and MSTO-211H) and one SV40-immortalized mesothelial cell line (MeT-5A) as a non-malignant model, with a library of 1170 FDA-approved drugs. Re ...[more]